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CAS 129938-20-1 Dapoxetine Hydrochloride

Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor marketed for the treatment of premature ejaculation in men. Premature ejaculation (PE) is the most common male sexual disorder, estimated to affect up to 30% of men.

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Product Description

Product Name:Dapoxetine Hydrochloride
Synonyms:Priligy;LY-21044;LY-210448;Dapoxetin HCl;DAPOXETINE HCL;Dapoxetine HCI;Rimonabant 75000;DL-Dapoxetine HCL;Dapoxetine HCL-IHS;(S)-N,N-dimethyl-3-
CAS NO:129938-20-1
Molecular Formula:C21H23NO·HCl
Molecular Weight:341.88
Melting Point:179.0 to 183.0 °C
Appearance:White to Almost white powder to crystal
Solubility:Chloroform (Slightly), Methanol (Slightly)



Dapoxetine, marketed as Priligy, among others, is a medication used for the treatment of premature ejaculation (PE) in men 18–64 years old. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the postsynaptic cleft, and as a consequence promoting ejaculatory delay. As a member of the selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast-acting property makes it suitable for the treatment of PE, but not as an antidepressant.

Medical uses

Premature ejaculation

Depression and anxiety


Adverse effects

The most common effects when taking dapoxetine are nausea, dizziness, dry mouth, headache, diarrhea, and insomnia. Discontinuation due to adverse effects is dose related. According to McMahon in a recent study in Asia, the rate of discontinuation is 0.3%, 1.7%, and 5.3% of 1067 studied subjects with placebo, dapoxetine 30 mg, and dapoxetine 60 mg, respectively. Unlike other SSRIs used to treat depression, which has been associated with high incidences of sexual dysfunction, dapoxetine is associated with low rates of sexual dysfunction. Taken as needed, dapoxetine has very mild adverse effects of decreased libido (<1%) and erectile dysfunction (<4%).

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