Product Description
Product Name: | Dapoxetine Hydrochloride |
Synonyms: | Priligy;LY-21044;LY-210448;Dapoxetin HCl;DAPOXETINE HCL;Dapoxetine HCI;Rimonabant 75000;DL-Dapoxetine HCL;Dapoxetine HCL-IHS;(S)-N,N-dimethyl-3- |
CAS NO: | 129938-20-1 |
Molecular Formula: | C21H23NO·HCl |
Molecular Weight: | 341.88 |
Melting Point: | 179.0 to 183.0 °C |
Appearance: | White to Almost white powder to crystal |
Storage: | 0-10°C |
Solubility: | Chloroform (Slightly), Methanol (Slightly) |
Introduction
Dapoxetine, marketed as Priligy, among others, is a medication used for the treatment of premature ejaculation (PE) in men 18–64 years old. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the postsynaptic cleft, and as a consequence promoting ejaculatory delay. As a member of the selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast-acting property makes it suitable for the treatment of PE, but not as an antidepressant.
Medical uses
Premature ejaculation
Depression and anxiety
Adverse effects
The most common effects when taking dapoxetine are nausea, dizziness, dry mouth, headache, diarrhea, and insomnia. Discontinuation due to adverse effects is dose related. According to McMahon in a recent study in Asia, the rate of discontinuation is 0.3%, 1.7%, and 5.3% of 1067 studied subjects with placebo, dapoxetine 30 mg, and dapoxetine 60 mg, respectively. Unlike other SSRIs used to treat depression, which has been associated with high incidences of sexual dysfunction, dapoxetine is associated with low rates of sexual dysfunction. Taken as needed, dapoxetine has very mild adverse effects of decreased libido (<1%) and erectile dysfunction (<4%).
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