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CAS 224785-90-4 Vardenafil

Vardenafil is a selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5).

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Vardenafil Description

Product Name:Vardenafil
Synonyms:1-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-piperazine hydrochloride trihydrate;Vardenafil hydrochloride trihydrate;2-{2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one;2-{2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride trihydrate
CAS NO:224785-90-4
Molecular Formula:C23H39ClN6O7S
Molecular Weight:579.11
Melting Point:230-235℃
Boiling Point:692.2°C at 760 mmHg
Density:~1.4 g/cm3 (Predicted)
Appearance:White crystalline powder.
Storage:Store at room temperature
Solubility:Soluble in water (0.11 mg/ml).

Medical use

Main article: PDE5 inhibitor

Vardenafil’s indications and contraindications are the same as with other PDE5 inhibitors; it is closely related in function to sildenafil citrate (Viagra) and tadalafil (Cialis). The difference between the vardenafil molecule and sildenafil citrate is a nitrogen atom’s position and the change of sildenafil’s piperazine ring methyl group to an ethyl group. Tadalafil is structurally different from both sildenafil and vardenafil. Vardenafil’s relatively short effective time is comparable to but somewhat longer than sildenafils. Vardenafil also does not have an effect on PDE6, which means that it does not have vision adverse effects.

Beyond its indications for erectile dysfunction, vardenafil may be effective in the treatment of premature ejaculation, where it may significantly increase the time from penetration to ejaculation.

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