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CAS 224785-91-5 Vardenafil Hydrochloride

Vardenafil Hcl is a PDE5 inhibitor used for treating erectile dysfunction.Target: PDE5Vardenafil specifically inhibited the hydrolysis of cGMP by PDE5 with an IC50 of 0.7 nM (6.6 nM). In contrast, the IC50 of vardenafil for PDE1 was 180 nM; for PDE6, 11 nM; for PDE2, PDE3 and PDE4, more than 1000 nM. Relative to PDE5, the ratios of the IC50 for PDE1 were 257 (60), for PDE6 16 (7.4). Vardenafil significantly enhanced the SNP-induced relaxation of human trabecular smooth muscle at 3 nM (10 nM). Vardenafil also significantly potentiated both ACh-induced and transmural electrical stimulation-induced relaxation of trabecular smooth muscle.

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Vardenafil Hydrochloride Description

Product Name:Vardenafil Hydrochloride
Synonyms:2-[2-Ethoxy-5-(4-ethyl piperazine-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one hydrochloride
CAS NO:224785-91-5
EINECS:606-590-1
Molecular Formula:C23H33ClN6O4S
Molecular Weight:525.06
Melting Point:214-216°C
Boiling Point:692.2°C at 760 mmHg
Flashpoint:372.5°C
Appearance:White to Off-White Crystalline Solid

 

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