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CAS 317318-70-0 GW-501516

An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream.A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPAR╬┤ agonist. Exhibits selectivity for PPAR╬┤ compared to PPARa and PPAR╬│. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells. GW 501516 has been found to enhance endurance in mice without any training.

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GW-501516 Description

Chemical NameGW 501516
Synonyms2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic Acid; Methyl-methyl-trifluoromethylphenyl
CAS Number317318-70-0
Alternate CAS #813458-54-7
Molecular FormulaC₂₁H₁₈F₃NO₃S₂
AppearanceWhite to Pale Yellow Solid
Melting Point134 – 144°C
Molecular Weight453.5
Storage4°C
SolubilityDMSO (Slightly), Methanol (Slightly)
CategoryStandards; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsAn experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream.A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPAR╬┤ agonist. Exhibits selectivity for PPAR╬┤ compared to PPARa and PPAR╬│. Does not exhibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells. GW 501516 has been found to enhance endurance in mice without any training.

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