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Yohimbine: Uses, Side Effects, and More

Yohimbine, also known as quebrachine, is an indole alkaloid derived from the bark of the African tree Pausinystalia Yohimbe; also from the bark of the unrelated South American tree Aspidosperma quebracho-blanco. Yohimbine is an α2-adrenergic receptor antagonist and has been used in a variety of research projects. It is a veterinary drug used to reverse sedation in dogs and deer.

While yohimbine behaves as an aphrodisiac in some mammals, it does not do so in humans. It has been prescribed as a treatment for erectile dysfunction, although its reported clinical benefits were modest and it has largely been superseded by the PDE5 inhibitor class of drugs. Substances that have purported to be extracted from the Yohimbe tree have been marketed as dietary supplements for various purposes, but they contain highly variable amounts of yohimbine if any; no published scientific evidence supports their efficacy.

Yohimbine Uses

Yohimbine is a drug used in veterinary medicine to reverse the effects of xylazine in dogs and deer. It is used as a research reagent. In the US, it is prescribed, but now rarely, for erectile dysfunction in men.

Yohimbine and yohimbe


Yohimbine should not be confused with Yohimbe but often is.

Yohimbe is the common English name for the tree species P. Yohimbe (also called Corynanthe Yohimbe) and, by extension, the name of a medicinal preparation made from the bark of that tree, sold as an aphrodisiac. In contrast, yohimbine is a pure alkaloid that can be isolated from Yohimbe bark.

Yohimbine is just one of at least 55 indole alkaloids that have been isolated from the bark; and, while it has been described as the most active of these, it constitutes only 15% of the total alkaloid content. Others include rauwolscine, coronatine, and ajmalicine; the bark also contains non-alkaloids about which virtually nothing is known.

Yohimbe, thus a complex mixture, has been studied far less thoroughly than yohimbine, the pure compound. Pharmaceutical grade yohimbine is usually presented as the hydrochloride, 3, 14, 34  which is more soluble.

Effect on sexual function

History, research, and literature

Yohimbe is used in folk medicine as an aphrodisiac. In 1900, it attracted scientific interest in Germany, where an initial report claimed that Yohimbe exerted a strong aphrodisiacal effect on animals and humans. Attention soon shifted from the plant to its active constituents, particularly yohimbine. According to a 2010 encyclopedia article by Joseph M. Betz of the National Institutes of Health:

Probably as a result of this trend, no reports of human studies on the effects of crude Yohimbe bark or its extracts on sexual performance can be found in the [scientific] literature… Any discussion of the use of the bark for sexual enhancement thus begins and ends with folklore.

In contrast, there is a “fairly rich literature on yohimbine”.

Subsequent work on yohimbine, while confirming that it behaves as an aphrodisiac in animals, including rats, dogs, and golden hamsters, has failed to do so in humans. According to Betz:

experiments show that the alkaloid increases sexual motivation even in sexually exhausted rats due to its action on the central α2-adrenoreceptors found in the locus coeruleus in the brain. Blockage of these brain adrenoreceptors appears to reverse a central negative feedback mechanism that regulates penile erection and maintains detumescence… [But] the compound does not increase sexual desire and thoughts in human clinical trials. The combined evidence from human and animal clinical studies indicates that yohimbine is far less potent in stimulating sexual behavior in humans than in rats. One possible explanation for this finding is the existence of powerful and multiple inhibitory controls on sexual behavior in humans that are not present in rats i.e. the cognitive aspects of sex are far more important in humans than the basic instinctive functions observed in animals.

Clinical efficacy

Yohimbine has been used to treat female sexual dysfunction, but there are few reported clinical trials and these do not show it to be better than a placebo. On treatment for male erectile dysfunction (ED), a review article by Tam et al. (2001) concluded:

Although well-tolerated and safe, even when greatly exceeding the likely therapeutic range, it is obvious that the efficacy of [yohimbine] as monotherapy in the general ED population is likely to be modest.

Again according to Betz (2010),

The modern consensus appears to be that the pure compound yohimbine is effective for treating certain mild types of erectile dysfunction in some men, but does not act as an aphrodisiac”.

A 2011 review by Andersson said:

The effects of yohimbine have been investigated in several controlled trials on patients with different types of ED, but the effect has been modest… It cannot be excluded that orally administered yohimbine may have a beneficial effect in some patients with ED. However, as a consequence of the conflicting results, it is not currently recommended in most guidelines for the management of ED.

Yohimbine has been largely superseded by PDE5 inhibitor drugs such as sildenafil (Viagra). Prescriptions for it are now rare, and most US pharmaceutical manufacturers have discontinued the production of prescription capsules and tablets.

Yohimbine has been found to be effective in treating delayed ejaculation in men 

Yohimbine and dietary supplements

In the US, “Yohimbe” preparations are sold as a dietary supplement for enhancing libido, for weight loss, and as aids for bodybuilding; but “There is virtually no published research on Yohimbe which supports these or any other claims”. Often, these products explicitly claim to contain yohimbine.

Cohen et al. found that samples of brands sold in American brick-and-mortar stores contained highly variable amounts of yohimbine, and sometimes none at all.  Labeling claims were often misleading.  Similar results have been reported by other laboratories for products sold in the U.S., in other countries, and on the internet. One study found that many brands of “Yohimbe” might not derive from the P. Yohimbe tree in the first place. According to yet another source, the Yohimbe sold in markets in West Africa, where the tree grows, is frequently adulterated with other species of the genus Pausinystalia; these contain little yohimbine. The amounts of alkaloids found even in genuine P. Yohimbe bark vary considerably, depending on the source of the bark (roots, stem, branches, height, etc.).

Some brands sold over-the-counter were found to contain more yohimbine per serving than a standard pharmaceutical dose; yet, in the US, pharmaceuticals are subject to the strict regulatory regime pertaining to medicines. It is illegal to introduce or deliver “drugs” into interstate commerce without the permission of the FDA. The FDA has asserted that some yohimbine-containing products are “drugs” because they are so promoted as to show “they are intended for use in the cure, mitigation, treatment or prevention of disease”: 21 U.S.C. § 321(g)(1)(B). However the legal position is not entirely straightforward, and as of 1 February 2019, there does not appear to be any record of a successful prosecution.

Because of the lack of reliable scientific data on Yohimbe, the European Food Safety Authority Panel on Food Additives determined that it was not possible to conclude its safety or to establish a health-based guidance value.  They wrote:

Overall the missing information includes [s] quantitative data on the composition and specifications of Yohimbe bark and its preparations used in food and food supplements covering other alkaloids besides yohimbine, data on the bioavailability of active ingredients from the Yohimbe bark extract and data on the toxicity of well specified individual preparations of Yohimbe bark and the major Yohimbe bark alkaloids, especially regarding subchronic toxicity, genotoxicity, and reproductive toxicity.

Extracts and chemistry

Yohimbe (Pausinystalia Yohimbe) is a tree that grows in western and central Africa; yohimbine was named as originally extracted from the bark of Yohimbe in 1896 by Adolph Spiegel (but see § Aspidosperma quebracho-blanco below). In 1943 the correct constitution of yohimbine was proposed by Witkop. Fifteen years later, a team led by Eugene van Tamelen used a 23-step synthesis to become the first persons to achieve the synthesis of yohimbine.


Yohimbine has a high affinity for the α2-adrenergic receptor, moderate affinity for the α1 receptor, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1F, 5-HT2B, and dopamine D2 receptors, and weak affinity for the 5-HT1E, 5-HT2A, 5-HT5A, 5-HT7, and dopamine D3 receptors. It behaves as an antagonist at α1-adrenergic, α2-adrenergic, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, and dopamine D2, and as a partial agonist at 5-HT1A. Yohimbine interacts with serotonin and dopamine receptors in high concentrations.


See also: Anabolic-androgenic steroids abuse § Childhood trauma

Yohimbine has been studied as a way to improve the effects of exposure therapy in people with post-traumatic stress disorder (PTSD), which passed a phase 2 study in 2017.

It has also been studied as a potential treatment for erectile dysfunction but there is insufficient evidence to rate its effectiveness. It is illegal in the United States to market an over-the-counter product containing yohimbine as a treatment for erectile dysfunction without getting FDA approval to do so. Nevertheless, the quantity of yohimbine in dietary supplements, often advertised as promoting sexual function, has been found to overlap with prescription doses of yohimbine.

Yohimbine blocks the pre-and post-synaptic α2 receptors. Blockade of post-synaptic α2 receptors causes only minor corpus cavernosum smooth muscle relaxation, due to the fact that the majority of adrenoceptors in the corpus cavernosum are of the α1 type. Blockade of pre-synaptic α2 receptors facilitates the release of several neurotransmitters in the central and peripheral nervous system — thus in the corpus cavernosum — such as nitric oxide and norepinephrine. Whereas nitric oxide released in the corpus cavernosum is the major vasodilator contributing to the erectile process, norepinephrine is the major vasoconstrictor through stimulation of α1 receptors on the corpus cavernosum smooth muscle. Under physiologic conditions, however, nitric oxide attenuates norepinephrine vasoconstriction.

Botanical sources of yohimbine; sustainability

Pausinystalia Yohimbe

The traditional source of yohimbine is the bark of the African tree P. Yohimbe. It has other uses, but the tree is sought out primarily for its bark; in practice, harvesting the bark kills the tree. Tree density is relatively low (average ≈ 4 harvestable trees/hectare). The high demand for medicines based on the bark has led to the tree’s over-exploitation. The bark is traded in local markets and, because it is scarce, it is often adulterated with that of other species which contain little yohimbine. The species is becoming endangered.

Around the year 2000, Cameroon was shipping P. Yohimbe to Europe at the rate of about 100 tonnes annually. Most bark is collected illegally by local people who are paid 150 CFA francs per kilo (about US$0.10 per pound) for delivery of pre-dried bark at the roadside. In practice, they confuse and mix it with P. macro ceras (“false Yohimbe”), a species that contains little yohimbine.

Aspidosperma quebracho-blanco

Aspidosperma quebracho-blanco is an unrelated tree whose common name is quebracho blanco. It is found in large areas of central South America, particularly the Gran Chaco, where it is often the dominant species in the canopy. It is one of the most widely distributed Argentine arboreal species. Traditionally it was logged for fuel, timber, and railway sleepers. While in recent times cattle ranching and soya cultivation have led to considerable habitat loss, and while there is still illegal logging, no shortage of the bark is reported. The tree has not been described as endangered: a few members of the genus Aspidosperma are on the IUCN Red List. but the quebracho blanco species is not one of them.

In its bark, an alkaloid is found which was given the name Quebrachine. In 1914, two scientific papers claimed quebrachine was chemically identical to yohimbine. This was disputed, and the matter long remained in doubt. However, in 1972, Effler and Effler using modern analytical techniques, including mass spectrometry, UV absorption, IR absorption, and NMR, established that quebrachine and yohimbine are one and the same thing. They wrote:

While it was almost unthinkable in 1914 … that the same alkaloid was formed in [completely] different plants, recent studies have shown that this is certainly the case for indole alkaloids.

A range of secondary reference works gives ‘quebrachine’ as a synonym for yohimbine.

Strictly speaking, wrote George Barger, yohimbine should have been given the scientific name quebrachine, seeing that it was first isolated from the quebracho tree and first named in the scientific literature. However the later work on P. yohimbe was better known, so the newer name stuck.

Other plants

Yohimbine has also been isolated from other plant genera in the family Apocynaceae including Lochnera (Catharanthus), Rauvolfia, Amsonia, Vallesia, and Vinca; from the family Loganiaceae (genera Gelsemium and Strychnos); and from the family Euphorbiaceae (genus Alchornea).


There was a case in the World Anti-Doping Agency practice in 2007, when an athlete, who reportedly consumed Yohimbine prior to a given athletic event, later tested positive for 19-nor androsterone, which is a prohibited substance. However, WADA did not yet list Yohimbine (which can come into a body via an energy drink, also in a form of a pre-workout supplement or fat burner) as a prohibited substance, nor did it confirm that its use can increase the endogenous level of anabolic steroids, in particular of 19-nor androstenedione and testosterone.